T (gen)

T (gen)
Identifikatori
Aliasi	TBXT
Vanjski ID-jevi	OMIM: 601397 MGI: 98472 HomoloGene: 2393 GeneCards: TBXT
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek)[1] Bend 6q27 Početak 166,157,656 bp[1] Kraj 166,168,700 bp[1]
Lokacija gena (miš) Hrom. Hromosom 17 (miš)[2] Bend 17 A1|17 4.92 cM Početak 8,653,255 bp[2] Kraj 8,661,328 bp[2]
Ontologija gena Molekularna funkcija • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • vezivanje sa DNK • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • citoplazma • Hromatin • jedro Biološki proces • somitogenesis • cellular response to retinoic acid • determination of heart left/right asymmetry • GO:0009373 regulation of transcription, DNA-templated • SMAD protein signal transduction • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • neural plate morphogenesis • bone morphogenesis • anatomical structure morphogenesis • heart morphogenesis • notochord development • signal transduction involved in regulation of gene expression • GO:1901227 negative regulation of transcription by RNA polymerase II • BMP signaling pathway • transcription, DNA-templated • embryonic skeletal system development • Vaskulogeneza • multicellular organism development • reproductive process • neural tube closure • positive regulation of cell population proliferation • Notohord • post-anal tail morphogenesis • canonical Wnt signaling pathway • mesoderm migration involved in gastrulation • mesoderm development • anterior/posterior axis specification, embryo • penetration of zona pellucida • primitive streak formation • GO:0072468 Transdukcija signala • anterior/posterior pattern specification • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of DNA-binding transcription factor activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6862	20997
Ensembl	ENSG00000164458	ENSMUSG00000062327
UniProt	O15178	P20293
RefSeq (mRNK)	NM_001270484 NM_003181 NM_001366285 NM_001366286	NM_009309
RefSeq (bjelančevina)	NP_001257413 NP_003172 NP_001353214 NP_001353215	NP_033335
Lokacija (UCSC)	Chr 6: 166.16 – 166.17 Mb	Chr 17: 8.65 – 8.66 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Brahiurija (stgrč. βραχύς – brahis = kratko + ουρά – ouria = rep) je stanje koje izaziva protein koji je kod ljudi kodiran genom TBXT (T-kutijski transkripcijski faktor T).^[5][6] Brahiurija funkcionira kao faktor transkripcije unutar porodice T-kutijskih gena.^[7] Brahiurijskli homolozi pronađeni su u svih pregledanih bilateralnih životinja, kao i u slatkovodnih knidarija roda hidra.^[7]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000164458 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000062327 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: T".
6. ^ Edwards YH, Putt W, Lekoape KM, Stott D, Fox M, Hopkinson DA, Sowden J (mart 1996). "The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27". Genome Research. 6 (3): 226–33. doi:10.1101/gr.6.3.226. PMID 8963900.
7. ^ ^{a b} Scholz CB, Technau U (januar 2003). "The ancestral role of Brachyury: expression of NemBra1 in the basal cnidarian Nematostella vectensis (Anthozoa)". Development Genes and Evolution. 212 (12): 563–70. doi:10.1007/s00427-002-0272-x. PMID 12536320. S2CID 25311702.